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<title>Marginal zone</title>

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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">Marginal zone</span></span>

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</style><div role="note" class="hatnote navigation-not-searchable">For the marginal zone in cortical development, see <a href="Cerebral_cortex#Layer_organisation" title="Cerebral cortex">Cerebral cortex § Layer organisation</a>.</div>

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</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background-color:dimgray; color: white">Marginal zone</th></tr><tr><td colspan="2" class="infobox-image"></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="Foundational_Model_of_Anatomy" title="Foundational Model of Anatomy">FMA</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://bioportal.bioontology.org/ontologies/FMA/?p=classes&conceptid=http%3A%2F%2Fpurl.org%2Fsig%2Font%2Ffma%2Ffma15852">15852</a></td></tr><tr><td colspan="2" class="infobox-below"><a href="Anatomical_terminology" title="Anatomical terminology">Anatomical terminology</a><div style="text-align: right;"></div></td></tr></tbody></table>

<p>The <b>marginal zone</b> is the region at the interface between the non-lymphoid <a href="Red_pulp" title="Red pulp">red pulp</a> and the <a href="Lymphoid" class="mw-redirect" title="Lymphoid">lymphoid</a> <a href="White-pulp" class="mw-redirect" title="White-pulp">white-pulp</a> of the <a href="Spleen" title="Spleen">spleen</a>. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)

</p><p>A marginal zone also exists in the <a href="Lymphoid_follicle" class="mw-redirect" title="Lymphoid follicle">lymphoid follicles</a> of <a href="Lymph_node" title="Lymph node">lymph nodes</a>.<sup id="cite_ref-sangle2024_1-0" class="reference"><a href="#cite_note-sangle2024-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Those marginal zones contain naive B cells and memory B cells.<sup id="cite_ref-sangle2024_1-1" class="reference"><a href="#cite_note-sangle2024-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> In contrast to the marginal zone of the spleen, they are not characterized by containing additional non-recirculating B2 cells.<sup id="cite_ref-Marginal-zone_B_cells_3-0" class="reference"><a href="#cite_note-Marginal-zone_B_cells-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2></div>

<p>It is composed of cells derived primarily from the <a href="Myeloid" class="mw-redirect" title="Myeloid">myeloid</a> compartment of <a href="Bone_marrow" title="Bone marrow">bone marrow</a> differentiation. More recently, a population of <a href="Neutrophil#Subpopulations" title="Neutrophil">neutrophil-killers</a> has been described to populate peripheral areas of the marginal zone.<sup id="cite_ref-B_cell–helper_neutrophils_4-0" class="reference"><a href="#cite_note-B_cell–helper_neutrophils-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>

At least three distinct cellular markers can be used to identify cells of the marginal zone, MOMA-1, ERTR-9 and <a href="MARCO" title="MARCO">MARCO</a>.

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<div class="mw-heading mw-heading3"><h3 id="Blood_flow">Blood flow</h3></div>

<p>The marginal zone (MZ) is a highly transited area that receives large amounts of blood from the general circulation. Remarkably, the splenic <a href="Microvessel" class="mw-redirect" title="Microvessel">microvasculature</a> shows striking differences in mice and humans. In humans, the spleen receives blood from the splenic artery, which branches into central and penicillar arterioles.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Owing to the absence of a histologically defined <a href="Marginal_sinus" title="Marginal sinus">marginal sinus</a>, the blood flowing in penicillar arterioles directly drains into capillaries of the red pulp and perifollicular zone. The perifollicular zone is a well-defined area of decreased resistance that separates the MZ from the red pulp. Both the perifollicular zone and the red pulp consist of an <a href="Open_circulatory_system" class="mw-redirect" title="Open circulatory system">open circulatory system</a> of blood-filled spaces known as splenic cords, which have no defined endothelial delimitation and are in close contact with the venous sinusoidal vessels of the red pulp.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Function">Function</h2></div>

<p>The major role of marginal zone is to trap <a href="Particulate" class="mw-redirect" title="Particulate">particulate</a> <a href="Antigen" title="Antigen">antigen</a> from the <a href="Circulatory_system" title="Circulatory system">circulation</a> and present the antigen to the lymphocytes of the spleen.

</p><p>Experiments have shown that inert <a href="Latex" title="Latex">latex</a> <a href="Beads" class="mw-redirect" title="Beads">beads</a> as well as live bacteria such as <a href="Escherichia_coli" title="Escherichia coli">Escherichia coli</a> and <a href="Listeria_monocytogenes" title="Listeria monocytogenes">Listeria monocytogenes</a> are trapped by the marginal zone. However, only <a href="Immunogenicity" title="Immunogenicity">immunogenic</a> substances, i.e. <a href="Bacteria" title="Bacteria">bacteria</a>, are trafficked to the T and B cell zones of the white-pulp and are efficiently presented to elicit an immune response.

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<div class="mw-heading mw-heading3"><h3 id="Lymphocytes">Lymphocytes</h3></div>

<p>Marginal zone <a href="Lymphocyte" title="Lymphocyte">lymphocytes</a> are a type of <a href="B_cell" title="B cell">B cell</a> (<a href="Marginal-zone_B_cell" title="Marginal-zone B cell">Marginal-zone B cell</a>, abbreviated "MZ B cell") created there, capable of binding <a href="IgM" class="mw-redirect" title="IgM">IgM</a>-antigen complexes. They are notable for their ability to serve several different roles in the <a href="Immune_system" title="Immune system">immune system</a>. MZ B cells express polyreactive <a href="B-cell_receptor" title="B-cell receptor">BCRs</a> that bind to multiple microbial molecular patterns.<sup id="cite_ref-Marginal-zone_B_cells_3-1" class="reference"><a href="#cite_note-Marginal-zone_B_cells-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading3"><h3 id="Marginal_zone_macrophages">Marginal zone macrophages</h3></div>

<p>Within the marginal zone there exists two types of macrophages that are unique to this area: the marginal zone macrophages and the marginal metallophilic macrophages. These two macrophage sub-types are characterized by the expression of SIGN-R1 on the marginal zone macrophages and CD169 (siglec-1, sialoadhesin) on the marginal metallophilic macrophages.

</p><p>In addition to the marginal zone B-cells that normally reside there, a number of other cell types that are present in the blood pass through the marginal zone e.g. lymphocytes and granulocytes. In addition, a large number of dendritic cells are thought to reside temporarily in the marginal zone before migrating into the white pulp following stimulation and antigen uptake, as well as a large number of lymphocytes remaining in the marginal zone for a period of time during the process of transmigration into the white pulp. It can be assumed that both of these cells will interact with the marginal zone macrophages.

</p><p>Recent studies have shown that the marginal zone macrophages possess both important innate functions, as well as being able to promote adaptive immune responses, so these macrophages can bridge the innate and adaptive immunity.

</p><p>The marginal zone macrophages have a variety of functions, one of which is the phagocytosis of blood-borne pathogens. Because of the anatomy of the marginal zone, the blood within it slows down and therefore the pathogens present in the systemic circulation are phagocytosed by both marginal zone macrophages. There is limited data regarding the specific roles of these two macrophage subsets in the uptake and eradication of pathogens. However there is evidence and reports that show there is a specific involvement of the various pathogen receptors on the marginal zone macrophages in recognising and eliminating certain pathogens, especially encapsulated bacteria. For example, the C-type lectin SIGN-R1 receptor (present on the marginal zone macrophages), mediates the recognition of pneumococcal saccharides and is necessary for <i>Streptococcus pneumoniae</i> clearance.

</p><p>Furthermore, both types of marginal zone macrophages are involved in the clearance and degradation of viruses e.g. cowpox virus and adenovirus serotype 5. Evidence has shown that the clearance of lymphocytic choriomeningitis virus by marginal zone macrophages is crucial to prevent the spreading of viral infections to peripheral organs.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>

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<ul><li><a href="Marginal_zone_B-cell_lymphoma" class="mw-redirect" title="Marginal zone B-cell lymphoma">Marginal zone B-cell lymphoma</a></li>

<li><a href="Humoral_immunity" title="Humoral immunity">Humoral immunity</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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</style><cite id="CITEREFSanglePernick2024" class="citation web cs1">Sangle, Nikhil; Pernick, Nat (2 December 2024) [Originally published 1 November 2013]. <a rel="nofollow" class="external text" href="https://www.pathologyoutlines.com/topic/lymphnodesanatomy.html#microscopichistologicdescription277013">"Lymph nodes & spleen, nonlymphoma: Anatomy & histology-lymph nodes"</a>. <i>Pathology Outlines</i><span class="reference-accessdate">. Retrieved <span class="nowrap">1 February</span> 2025</span>.</cite></span>

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<li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><cite id="CITEREFKojimaNakamuraMotooriShimizu2002" class="citation journal cs1">Kojima, Masaru; Nakamura, Shigeo; Motoori, Tadashi; Shimizu, Kazuhiko; Ohno, Yoshihiro; Itoh, Hideakki; Masawa, Nobuhide (2002). "Follicular hyperplasia presenting with a marginal zone pattern in a reactive lymph node lesion". <i>APMIS</i>. <b>110</b> (4): <span class="nowrap">325–</span>331. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1034%2Fj.1600-0463.2002.100407.x">10.1034/j.1600-0463.2002.100407.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12076268">12076268</a>.</cite></span>

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<li id="cite_note-Marginal-zone_B_cells-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-Marginal-zone_B_cells_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Marginal-zone_B_cells_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFMartinKearney2002" class="citation journal cs1">Martin, Flavius; Kearney, John F. (May 2002). "Marginal-zone B cells". <i>Nature Reviews Immunology</i>. <b>2</b> (5): <span class="nowrap">323–</span>35. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnri799">10.1038/nri799</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12033738">12033738</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:22573840">22573840</a>.</cite></span>

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<li id="cite_note-B_cell–helper_neutrophils-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-B_cell–helper_neutrophils_4-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFPugaColsBarraHe2011" class="citation journal cs1">Puga, Irene; Cols, Montserrat; Barra, Carolina M; He, Bing; Cassis, Linda; Gentile, Maurizio; Chen, Kang; Cerutti, Andrea (December 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262910">"B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen"</a>. <i>Nature Immunology</i>. <b>13</b> (2): <span class="nowrap">170–</span>80. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fni.2194">10.1038/ni.2194</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262910">3262910</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22197976">22197976</a>.</cite></span>

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<li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><cite id="CITEREFMebiusKraal2005" class="citation journal cs1">Mebius, Reina E.; Kraal, Georg (August 2005). "Structure and function of the spleen". <i>Nature Reviews Immunology</i>. <b>5</b> (1): <span class="nowrap">606–</span>616. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnri1669">10.1038/nri1669</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16056254">16056254</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:3258595">3258595</a>.</cite></span>

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<li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><cite id="CITEREFSteinigerTimphusBarth2006" class="citation journal cs1">Steiniger, Birte; Timphus, Eva Maria; Barth, Peter J. (December 2006). "The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitants". <i>Histochemistry and Cell Biology</i>. <b>126</b> (6): <span class="nowrap">641–</span>648. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00418-006-0210-5">10.1007/s00418-006-0210-5</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16816939">16816939</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:31943597">31943597</a>.</cite></span>

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<li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><cite id="CITEREFden_HaanKraal2012" class="citation journal cs1">den Haan, Joke M.M.; Kraal, Georg (2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741446">"Innate Immune Functions of Macrophage Subpopulations in the Spleen"</a>. <i>Journal of Innate Immunity</i>. <b>4</b> (<span class="nowrap">5–</span>6): <span class="nowrap">437–</span>445. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000335216">10.1159/000335216</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1662-8128">1662-8128</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741446">6741446</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22327291">22327291</a>.</cite></span>

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<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

<ul><li><cite id="CITEREFPillaiCariappaMoran2005" class="citation journal cs1">Pillai S, Cariappa A, Moran ST (2005). "Marginal zone B cells". <i>Annual Review of Immunology</i>. <b>23</b>: <span class="nowrap">161–</span>96. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev.immunol.23.021704.115728">10.1146/annurev.immunol.23.021704.115728</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15771569">15771569</a>.</cite></li>

<li><cite id="CITEREFFergusonCorley2005" class="citation journal cs1">Ferguson AR, Corley RB (2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087843">"Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-κB p50-deficient mice"</a>. <i>BMC Immunology</i>. <b>6</b>: 8. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1471-2172-6-8">10.1186/1471-2172-6-8</a></span>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087843">1087843</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15836790">15836790</a>.</cite></li>

<li><a rel="nofollow" class="external text" href="http://www.lymphomation.org/type-mz.htm">Marginal zone lymphomas</a></li>

<li><cite id="CITEREFSongCerny2003" class="citation journal cs1">Song H, Cerny J (December 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194154">"Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen"</a>. <i>The Journal of Experimental Medicine</i>. <b>198</b> (12): <span class="nowrap">1923–</span>35. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1084%2Fjem.20031498">10.1084/jem.20031498</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194154">2194154</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14662910">14662910</a>.</cite></li>

<li><cite id="CITEREFKraal_G1992" class="citation journal cs1">Kraal G (1992). "Cells in the marginal zone of the spleen". <i>International Review of Cytology</i>. <b>132</b>: <span class="nowrap">31–</span>74. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0074-7696%2808%2962453-5">10.1016/S0074-7696(08)62453-5</a>. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>9780123645326</bdi>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1555921">1555921</a>.</cite></li>

<li><cite id="CITEREFKumararatneMacLennan1981" class="citation journal cs1">Kumararatne DS, MacLennan IC (November 1981). "Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors". <i>European Journal of Immunology</i>. <b>11</b> (11): <span class="nowrap">865–</span>9. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Feji.1830111104">10.1002/eji.1830111104</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/6976895">6976895</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:22799132">22799132</a>.</cite></li></ul>

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</style><div id="Organs_of_the_lymphatic_system122" style="font-size:114%;margin:0 4em">Organs of the <a href="Lymphatic_system" title="Lymphatic system">lymphatic system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Primary_lymphoid_organs" class="mw-redirect" title="Primary lymphoid organs">Primary organs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Bone_marrow" title="Bone marrow">Bone marrow</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Hematopoietic_stem_cell" title="Hematopoietic stem cell">Hematopoietic stem cell</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Thymus" title="Thymus">Thymus</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Hassall's_corpuscles" title="Hassall's corpuscles">Hassall's corpuscles</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Secondary_lymphoid_organs" class="mw-redirect" title="Secondary lymphoid organs">Secondary organs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Spleen" title="Spleen">Spleen</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li>Parts

<ul><li><a href="Splenic_hilum" class="mw-redirect" title="Splenic hilum">Hilum</a></li>

<li><a href="Trabeculae_of_spleen" title="Trabeculae of spleen">Trabeculae</a></li></ul></li>

<ul><li><a href="Cords_of_Billroth" title="Cords of Billroth">Cords of Billroth</a></li>

</ul></li>

<li><a href="White_pulp" title="White pulp">White pulp</a>

<ul><li><a href="Periarteriolar_lymphoid_sheaths" title="Periarteriolar lymphoid sheaths">Periarteriolar lymphoid sheaths</a></li>

<li><a href="Germinal_center" title="Germinal center">Germinal center</a></li></ul></li>

<li>Blood vessels

<ul><li><a href="Trabecular_arteries" title="Trabecular arteries">Trabecular arteries</a></li>

<li><a href="Trabecular_veins" title="Trabecular veins">Trabecular veins</a></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Tonsil" title="Tonsil">Tonsils</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Palatine_tonsil" title="Palatine tonsil">Palatine</a></li>

<li><a href="Lingual_tonsils" title="Lingual tonsils">Lingual</a></li>

<li><a href="Pharyngeal_tonsil" class="mw-redirect" title="Pharyngeal tonsil">Pharyngeal</a></li>

<li><a href="Tubal_tonsil" title="Tubal tonsil">Tubal</a></li>

<li><a href="Tonsillar_crypts" title="Tonsillar crypts">Tonsillar crypts</a></li>

<li><a href="Waldeyer's_tonsillar_ring" title="Waldeyer's tonsillar ring">Waldeyer's tonsillar ring</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Lymph_node" title="Lymph node">Lymph nodes</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Lymphatic_vessel" title="Lymphatic vessel">Lymphatic vessel</a></li>

<li><a href="T_cell" title="T cell">T cells</a>

<ul><li><a href="High_endothelial_venules" title="High endothelial venules">High endothelial venules</a></li></ul></li>

<li><a href="B_cell" title="B cell">B cells</a>

<ul><li><a href="Germinal_center" title="Germinal center">Germinal center</a></li>

<li><a href="Mantle_zone" title="Mantle zone">Mantle zone</a></li>

</ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Mucosa-associated_lymphoid_tissue" title="Mucosa-associated lymphoid tissue">MALT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<li><a href="Peyer's_patch" title="Peyer's patch">Peyer's patch</a></li>

<li><a href="Germinal_center" title="Germinal center">Germinal center</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table></div></div><div><div class="zim-footer">

This article is issued from <a class="external text" title="Last edited on 2025-02-01" href="https://en.wikipedia.org/wiki/?title=Marginal_zone&oldid=1273260561">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.

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